6QLY

IDOL FERM domain

Summary for 6QLY

• Entry DOI: 10.2210/pdb6qly/pdb
• Descriptor: E3 ubiquitin-protein ligase MYLIP, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: ferm domain; ubiquitin e3 ligase cholesterol metabolism, ldlr degradation, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 39160.70

Authors

Martinelli, L.,Sixma, T.K. (deposition date: 2019-02-01, release date: 2020-02-19, Last modification date: 2024-01-24)

• Primary citation: Martinelli, L.,Adamopoulos, A.,Johansson, P.,Wan, P.T.,Gunnarsson, J.,Guo, H.,Boyd, H.,Zelcer, N.,Sixma, T.K.; Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.; J.Biol.Chem., 295:13570-13583, 2020; PubMed: 32727844; DOI: 10.1074/jbc.RA120.014349

Experimental method

X-RAY DIFFRACTION (2.5 Å)