6QCH

Human Sirt6 in complex with ADP-ribose and the activator cyanidin

Summary for 6QCH

• Entry DOI: 10.2210/pdb6qch/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (7 entities in total)
• Functional Keywords: deacylase, activator, quercetin derivative, allosteric, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 70296.03

Authors

You, W.,Steegborn, C. (deposition date: 2018-12-28, release date: 2019-12-25, Last modification date: 2024-01-24)

• Primary citation: You, W.,Zheng, W.,Weiss, S.,Chua, K.F.,Steegborn, C.; Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.; Sci Rep, 9:19176-19176, 2019; PubMed: 31844103; DOI: 10.1038/s41598-019-55654-1

Experimental method

X-RAY DIFFRACTION (2.1 Å)