6Q1N
Glucocerebrosidase in complex with pharmacological chaperone IMX8
Summary for 6Q1N
Entry DOI | 10.2210/pdb6q1n/pdb |
Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | pharmacological chaperone, gaucher disease, glycosidase, inhibitor, pka, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 116141.78 |
Authors | |
Primary citation | Santana, A.G.,Robinson, K.,Vickers, C.,Chen, H.,Zhou, S.,Boraston, A.B.,Clarke, L.A.,Withers, S.G. Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models. To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.526 Å) |
Structure validation
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