6POC
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-(3-(Aminomethyl)-4-(oxazol-4-ylmethoxy)phenyl)-4-methylquinolin-2-amine
Summary for 6POC
| Entry DOI | 10.2210/pdb6poc/pdb |
| Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 7-{3-(aminomethyl)-4-[(1,3-oxazol-4-yl)methoxy]phenyl}-4-methylquinolin-2-amine, ... (6 entities in total) |
| Functional Keywords | nitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 100585.29 |
| Authors | Li, H.,Poulos, T.L. (deposition date: 2019-07-03, release date: 2020-04-29, Last modification date: 2023-10-11) |
| Primary citation | Cinelli, M.A.,Reidl, C.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B. First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63:4528-4554, 2020 Cited by PubMed: 32302123DOI: 10.1021/acs.jmedchem.9b01573 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.998 Å) |
Structure validation
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