6PBJ
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase with Gly190Pro mutation
Summary for 6PBJ
Entry DOI | 10.2210/pdb6pbj/pdb |
Descriptor | Phospho-2-dehydro-3-deoxyheptonate aldolase, PHOSPHATE ION, SULFATE ION, ... (8 entities in total) |
Functional Keywords | dah7ps, allostery, shipmate pathway, tim barrel, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 103444.53 |
Authors | Jiao, W.,Fan, Y.,Blackmore, N.J.,Parker, E.J. (deposition date: 2019-06-13, release date: 2020-04-08, Last modification date: 2023-10-11) |
Primary citation | Jiao, W.,Fan, Y.,Blackmore, N.J.,Parker, E.J. A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis . J.Biol.Chem., 295:6252-6262, 2020 Cited by PubMed: 32217694DOI: 10.1074/jbc.RA120.012605 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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