6P9B

HIV-1 Protease multiple drug resistant mutant PRS5B with Amprenavir

Summary for 6P9B

Entry DOI	10.2210/pdb6p9b/pdb
Related	3NU3
Descriptor	HIV-1 protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	protease, inhibitor, multiple mutant, hydrolase-hydrolase inhibitor, viral protein complex, hydrolase/hydrolase inhibitor, viral protein
Biological source	Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
Total number of polymer chains	2
Total formula weight	22326.62
Authors	Kneller, D.W.,Agniswamy, J.,Weber, I.T. (deposition date: 2019-06-10, release date: 2020-04-15, Last modification date: 2023-10-11)
Primary citation	Kneller, D.W.,Agniswamy, J.,Harrison, R.W.,Weber, I.T. Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations. Febs J., 287:3235-3254, 2020 Cited by PubMed: 31920003 DOI: 10.1111/febs.15207 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation