6P83
E.coli LpxD in complex with compound 1o
Summary for 6P83
Entry DOI | 10.2210/pdb6p83/pdb |
Descriptor | UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase, MAGNESIUM ION, 4-(2-chlorophenyl)-3-hydroxy-7,7-dimethyl-2-phenyl-2,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one, ... (4 entities in total) |
Functional Keywords | lps synthesis, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 3 |
Total formula weight | 109606.19 |
Authors | |
Primary citation | Ma, X.,Prathapam, R.,Wartchow, C.,Chie-Leon, B.,Ho, C.M.,De Vicente, J.,Han, W.,Li, M.,Lu, Y.,Ramurthy, S.,Shia, S.,Steffek, M.,Uehara, T. Structural and Biological Basis of Small Molecule Inhibition ofEscherichia coliLpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis. Acs Infect Dis., 6:1480-1489, 2020 Cited by PubMed: 31402665DOI: 10.1021/acsinfecdis.9b00127 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report