6P4B

HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S)

Summary for 6P4B

• Entry DOI: 10.2210/pdb6p4b/pdb
• Descriptor: HyHEL10 Fab light chain, HyHEL10 Fab heavy chain, Lysozyme C, ... (5 entities in total)
• Functional Keywords: hel2x-flex, hyhel10-4x, fab, antigen-antibody, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 124604.40

Authors

Langley, D.B.,Christ, D. (deposition date: 2019-05-27, release date: 2020-05-27, Last modification date: 2023-10-11)

• Primary citation: Burnett, D.L.,Schofield, P.,Langley, D.B.,Jackson, J.,Bourne, K.,Wilson, E.,Porebski, B.T.,Buckle, A.M.,Brink, R.,Goodnow, C.C.,Christ, D.; Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.; Proc.Natl.Acad.Sci.USA, 117:22341-22350, 2020; PubMed: 32855302; DOI: 10.1073/pnas.2005102117

Experimental method

X-RAY DIFFRACTION (1.9 Å)