6P1D

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

Summary for 6P1D

Entry DOI	10.2210/pdb6p1d/pdb
Descriptor	Epidermal growth factor receptor, 10-benzyl-8-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	egfr, cancer, inhibitor, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	152646.18
Authors	Heppner, D.E.,Eck, M.J. (deposition date: 2019-05-19, release date: 2019-12-18, Last modification date: 2023-10-11)
Primary citation	De Clercq, D.J.H.,Heppner, D.E.,To, C.,Jang, J.,Park, E.,Yun, C.H.,Mushajiang, M.,Shin, B.H.,Gero, T.W.,Scott, D.A.,Janne, P.A.,Eck, M.J.,Gray, N.S. Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. Acs Med.Chem.Lett., 10:1549-1553, 2019 Cited by PubMed: 31749909 DOI: 10.1021/acsmedchemlett.9b00381 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation