6OJD

A high-resolution crystal structure of covalent complex of NocB thioesterase domain with fluorophosphonate nocardicin G analog

Summary for 6OJD

• Entry DOI: 10.2210/pdb6ojd/pdb
• Related: 6OJC
• Descriptor: NocB, GLYCEROL, (R)-[(S)-[(3S)-3-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoazetidin-1-yl](4-hydroxyphenyl)methyl]methylphosphinic acid, ... (5 entities in total)
• Functional Keywords: nonribosomal peptide synthetase (nrps), thioesterase, epimerization, alpha/beta hydrolase fold, hydrolase
• Biological source: Nocardia uniformis subsp. tsuyamanensis
• Total number of polymer chains: 4
• Total formula weight: 113918.42

Authors

Patel, K.D.,Gulick, A.M. (deposition date: 2019-04-11, release date: 2019-09-11, Last modification date: 2023-10-11)

• Primary citation: Patel, K.D.,d'Andrea, F.B.,Gaudelli, N.M.,Buller, A.R.,Townsend, C.A.,Gulick, A.M.; Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions.; Nat Commun, 10:3868-3868, 2019; PubMed: 31455765; DOI: 10.1038/s41467-019-11740-6

Experimental method

X-RAY DIFFRACTION (1.99 Å)