6OIP
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 34
Summary for 6OIP
Entry DOI | 10.2210/pdb6oip/pdb |
Descriptor | Histone acetyltransferase KAT8, ZINC ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, myst, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32748.04 |
Authors | Hermans, S.J.,Chung, M.C.,Parker, M.W.,Thomas, T.,Baell, J.B. (deposition date: 2019-04-09, release date: 2019-07-03, Last modification date: 2023-11-15) |
Primary citation | Leaver, D.J.,Cleary, B.,Nguyen, N.,Priebbenow, D.L.,Lagiakos, H.R.,Sanchez, J.,Xue, L.,Huang, F.,Sun, Y.,Mujumdar, P.,Mudududdla, R.,Varghese, S.,Teguh, S.,Charman, S.A.,White, K.L.,Katneni, K.,Cuellar, M.,Strasser, J.M.,Dahlin, J.L.,Walters, M.A.,Street, I.P.,Monahan, B.J.,Jarman, K.E.,Sabroux, H.J.,Falk, H.,Chung, M.C.,Hermans, S.J.,Parker, M.W.,Thomas, T.,Baell, J.B. Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62:7146-7159, 2019 Cited by PubMed: 31256587DOI: 10.1021/acs.jmedchem.9b00665 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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