6OFD

The crystal structure of octadecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase

Summary for 6OFD

Entry DOI	10.2210/pdb6ofd/pdb
Descriptor	Fe(3+)-Zn(2+) purple acid phosphatase, [(S)-(naphthalen-1-yl)(octadecyloxy)methyl]phosphonic acid, SODIUM ION, ... (17 entities in total)
Functional Keywords	purple acid phosphatase, metallohydrolases, transition state, catalysis, osteoporosis, metal binding protein
Biological source	Phaseolus vulgaris (Kidney bean)
Total number of polymer chains	4
Total formula weight	223835.76
Authors	Feder, D.,Schenk, G.,Guddat, L.W.,Hussein, W.M.,McGeary, R.P.,Kan, M.W. (deposition date: 2019-03-29, release date: 2019-09-04, Last modification date: 2023-10-11)
Primary citation	Feder, D.,Kan, M.W.,Hussein, W.M.,Guddat, L.W.,Schenk, G.,McGeary, R.P. Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. Eur.J.Med.Chem., 182:111611-111611, 2019 Cited by PubMed: 31445230 DOI: 10.1016/j.ejmech.2019.111611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation