6OC1

Crystal structure of human DHODH with TAK-632

Summary for 6OC1

Entry DOI	10.2210/pdb6oc1/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, OROTIC ACID, FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
Functional Keywords	dhodh, inhibitor, tak-632, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41387.80
Authors	Durst, M.A.,Lavie, A. (deposition date: 2019-03-21, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citation	Abt, E.R.,Rosser, E.W.,Durst, M.A.,Lok, V.,Poddar, S.,Le, T.M.,Cho, A.,Kim, W.,Wei, L.,Song, J.,Capri, J.R.,Xu, S.,Wu, N.,Slavik, R.,Jung, M.E.,Damoiseaux, R.,Czernin, J.,Donahue, T.R.,Lavie, A.,Radu, C.G. Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism. Cell Chem Biol, 27:197-, 2020 Cited by PubMed: 31734178 DOI: 10.1016/j.chembiol.2019.10.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation