6O4L

Structure of ALDH7A1 mutant E399D complexed with NAD

Summary for 6O4L

Entry DOI	10.2210/pdb6o4l/pdb
Descriptor	Alpha-aminoadipic semialdehyde dehydrogenase, 1,2-ETHANEDIOL, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	aldehyde dehydrogenase, nad, oxidoreductase, lysine catabolism
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	225398.24
Authors	Tanner, J.J.,Korasick, D.A.,Laciak, A.R. (deposition date: 2019-02-28, release date: 2019-11-06, Last modification date: 2023-10-11)
Primary citation	Laciak, A.R.,Korasick, D.A.,Gates, K.S.,Tanner, J.J. Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy. J. Inherit. Metab. Dis., 43:635-644, 2020 Cited by PubMed: 31652343 DOI: 10.1002/jimd.12184 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation