6O28

Crystal structure of 4493 Fab in complex with circumsporozoite protein KQPA and anti-kappa VHH domain

Summary for 6O28

• Entry DOI: 10.2210/pdb6o28/pdb
• Related: 6O23 6O24 6O25 6O26 6O27
• Descriptor: 4493 Fab heavy chain, 4493 Kappa light chain, Circumsporozoite protein, ... (6 entities in total)
• Functional Keywords: malaria, antibody, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 120631.49

Authors

Scally, S.W.,Bosch, A.,Prieto, K.,Murugan, R.,Wardemann, H.,Julien, J.P. (deposition date: 2019-02-22, release date: 2020-07-01, Last modification date: 2024-04-03)

• Primary citation: Murugan, R.,Scally, S.W.,Costa, G.,Mustafa, G.,Thai, E.,Decker, T.,Bosch, A.,Prieto, K.,Levashina, E.A.,Julien, J.P.,Wardemann, H.; Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs.; Nat. Med., 26:1135-1145, 2020; PubMed: 32451496; DOI: 10.1038/s41591-020-0881-9

Experimental method

X-RAY DIFFRACTION (1.93 Å)