6NE7

Structure of G810A mutant of RET protein tyrosine kinase domain.

Summary for 6NE7

Entry DOI	10.2210/pdb6ne7/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase receptor Ret, FORMIC ACID, ADENOSINE MONOPHOSPHATE, ... (4 entities in total)
Functional Keywords	transferase, oncogene, ret, tyrosine kinase, atp-binding, thyroid cancer, non-small cell lung cancer
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36321.49
Authors	Terzyan, S.S.,Shen, T.,Wu, J.,Mooers, B.H.M. (deposition date: 2018-12-17, release date: 2019-06-05, Last modification date: 2023-11-15)
Primary citation	Terzyan, S.S.,Shen, T.,Liu, X.,Huang, Q.,Teng, P.,Zhou, M.,Hilberg, F.,Cai, J.,Mooers, B.H.M.,Wu, J. Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294:10428-10437, 2019 Cited by PubMed: 31118272 DOI: 10.1074/jbc.RA119.007682 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation