6NCF
The structure of Stable-5-Lipoxygenase bound to AKBA
Summary for 6NCF
| Entry DOI | 10.2210/pdb6ncf/pdb |
| Descriptor | Arachidonate 5-lipoxygenase, FE (II) ION, (3alpha,8alpha,17alpha,18alpha)-3-(acetyloxy)-11-oxours-12-en-23-oic acid (3 entities in total) |
| Functional Keywords | lipoxygenase, inhibitor, allostery, complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 318481.07 |
| Authors | Newcomer, M.E.,Gilbert, N.C.,Neau, D.B. (deposition date: 2018-12-11, release date: 2020-05-13, Last modification date: 2020-07-08) |
| Primary citation | Gilbert, N.C.,Gerstmeier, J.,Schexnaydre, E.E.,Borner, F.,Garscha, U.,Neau, D.B.,Werz, O.,Newcomer, M.E. Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nat.Chem.Biol., 16:783-790, 2020 Cited by PubMed: 32393899DOI: 10.1038/s41589-020-0544-7 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.871 Å) |
Structure validation
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