6NAE

Crystal Structure of Ebola zaire GP protein with bound ARN0074898

Summary for 6NAE

• Entry DOI: 10.2210/pdb6nae/pdb
• Descriptor: Envelope glycoprotein,Envelope glycoprotein,Envelope glycoprotein, Envelope glycoprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: ssgcid, ebola zaire, glycoprotein, structural genomics, seattle structural genomics center for infectious disease, viral protein
• Biological source: Zaire ebolavirus (strain Mayinga-76) (ZEBOV); More
• Total number of polymer chains: 2
• Total formula weight: 57847.70

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2018-12-05, release date: 2019-12-11, Last modification date: 2023-10-11)

• Primary citation: Plewe, M.B.,Sokolova, N.V.,Gantla, V.R.,Brown, E.R.,Naik, S.,Fetsko, A.,Lorimer, D.D.,Dranow, D.M.,Smutney, H.,Bullen, J.,Sidhu, R.,Master, A.,Wang, J.,Kallel, E.A.,Zhang, L.,Kalveram, B.,Freiberg, A.N.,Henkel, G.,McCormack, K.; Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors.; Acs Med.Chem.Lett., 11:1160-1167, 2020; PubMed: 32550996; DOI: 10.1021/acsmedchemlett.0c00025

Experimental method

X-RAY DIFFRACTION (2.75 Å)