6N2E

Crystal Structure of Human Protocadherin-15 EC1-3 G16D N369D Q370N and Mouse Cadherin-23 EC1-2 T15E

Summary for 6N2E

Entry DOI	10.2210/pdb6n2e/pdb
Descriptor	Protocadherin-15, Cadherin-23, CALCIUM ION, ... (4 entities in total)
Functional Keywords	mechanotransduction, calcium-binding protein, stereocilia, hair cell, tip link, cell adhesion
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	134628.61
Authors	Choudhary, D.,De-la-Torre, P.,Sotomayor, M. (deposition date: 2018-11-12, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citation	Choudhary, D.,Narui, Y.,Neel, B.L.,Wimalasena, L.N.,Klanseck, C.F.,De-la-Torre, P.,Chen, C.,Araya-Secchi, R.,Tamilselvan, E.,Sotomayor, M. Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception. Proc.Natl.Acad.Sci.USA, 117:24837-24848, 2020 Cited by PubMed: 32963095 DOI: 10.1073/pnas.1920444117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation