6MWE

CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919

Summary for 6MWE

• Entry DOI: 10.2210/pdb6mwe/pdb
• Descriptor: Angiopoietin-1 receptor, SULFATE ION, 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: tie2, dp1919, emeraldbio, deciphera, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 73998.08

Authors

Chun, L.,Abendroth, J.,Edwards, T.E. (deposition date: 2018-10-29, release date: 2018-11-21, Last modification date: 2023-10-11)

• Primary citation: Harney, A.S.,Karagiannis, G.S.,Pignatelli, J.,Smith, B.D.,Kadioglu, E.,Wise, S.C.,Hood, M.M.,Kaufman, M.D.,Leary, C.B.,Lu, W.P.,Al-Ani, G.,Chen, X.,Entenberg, D.,Oktay, M.H.,Wang, Y.,Chun, L.,De Palma, M.,Jones, J.G.,Flynn, D.L.,Condeelis, J.S.; The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2; Mol. Cancer Ther., 16:2486-2501, 2017; PubMed: 28838996; DOI: 10.1158/1535-7163.MCT-17-0241

Experimental method

X-RAY DIFFRACTION (2.05 Å)