6MIH

Crystal structure of host-guest complex with PC hachimoji DNA

Summary for 6MIH

• Entry DOI: 10.2210/pdb6mih/pdb
• Descriptor: N-terminal fragment of MMLV reverse transcriptase, DNA (5'-D(*CP*TP*TP*AP*(1WA)P*CP*(DB)P*T)-3'), DNA (5'-D(P*AP*(DS)P*GP*(1W5)P*TP*AP*AP*G)-3'), ... (4 entities in total)
• Functional Keywords: host-guest complex, hachimoji dna, n-terminal fragment of mmlv rt, dna, hydrolase-dna complex, hydrolase/dna
• Biological source: Moloney murine leukemia virus (isolate Shinnick) (MoMLV); More
• Total number of polymer chains: 3
• Total formula weight: 34261.04

Authors

Georgiadis, M.M. (deposition date: 2018-09-19, release date: 2019-02-27, Last modification date: 2024-03-13)

• Primary citation: Hoshika, S.,Leal, N.A.,Kim, M.J.,Kim, M.S.,Karalkar, N.B.,Kim, H.J.,Bates, A.M.,Watkins Jr., N.E.,SantaLucia, H.A.,Meyer, A.J.,DasGupta, S.,Piccirilli, J.A.,Ellington, A.D.,SantaLucia Jr., J.,Georgiadis, M.M.,Benner, S.A.; Hachimoji DNA and RNA: A genetic system with eight building blocks.; Science, 363:884-887, 2019; PubMed: 30792304; DOI: 10.1126/science.aat0971

Experimental method

X-RAY DIFFRACTION (1.6 Å)