6MGQ

ERAP1 in the open conformation bound to 10mer phosphinic inhibitor DG014

Summary for 6MGQ

• Entry DOI: 10.2210/pdb6mgq/pdb
• Related PRD ID: PRD_002326
• Descriptor: Endoplasmic reticulum aminopeptidase 1, Phosphinic inhibitor DG014, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: inhibitor, aminopeptidase, immune system, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 332958.36

Authors

Stern, L.J.,Maben, Z. (deposition date: 2018-09-14, release date: 2019-12-18, Last modification date: 2023-10-11)

• Primary citation: Maben, Z.,Arya, R.,Georgiadis, D.,Stratikos, E.,Stern, L.J.; Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.; Nat Commun, 12:5302-5302, 2021; PubMed: 34489420; DOI: 10.1038/s41467-021-25564-w

Experimental method

X-RAY DIFFRACTION (2.92 Å)