6MFW

Crystal structure of a 4-domain construct of LgrA in the substrate donation state

Summary for 6MFW

Entry DOI	10.2210/pdb6mfw/pdb
Descriptor	Linear gramicidin synthase subunit A, (2~{R})-~{N}-[3-[2-[[(2~{S})-2-formamido-3-methyl-butanoyl]amino]ethylamino]-3-oxidanylidene-propyl]-3,3-dimethyl-2-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-butanamide, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, ... (8 entities in total)
Functional Keywords	nonribosomal peptide synthetase, tailoring domain, nrps, enzyme, natural product, linear gramicidin, ligase
Biological source	Brevibacillus parabrevis
Total number of polymer chains	1
Total formula weight	139739.89
Authors	Reimer, J.M.,Eivaskhani, M.,Schmeing, T.M. (deposition date: 2018-09-12, release date: 2019-11-20, Last modification date: 2023-10-11)
Primary citation	Reimer, J.M.,Eivaskhani, M.,Harb, I.,Guarne, A.,Weigt, M.,Schmeing, T.M. Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science, 366:-, 2019 Cited by PubMed: 31699907 DOI: 10.1126/science.aaw4388 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation