6MC1

Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor

Summary for 6MC1

• Entry DOI: 10.2210/pdb6mc1/pdb
• Descriptor: Dual specificity protein phosphatase 10, 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• Functional Keywords: phosphatase, protein-tyrosine phosphatase, dual specificity phosphatase, phosphatase-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 107717.36

Authors

Gannam, Z.T.K.,Anderson, K.S.,Bennett, A.M.,Lolis, E. (deposition date: 2018-08-30, release date: 2020-08-19, Last modification date: 2023-10-11)

• Primary citation: Gannam, Z.T.K.,Min, K.,Shillingford, S.R.,Zhang, L.,Herrington, J.,Abriola, L.,Gareiss, P.C.,Pantouris, G.,Tzouvelekis, A.,Kaminski, N.,Zhang, X.,Yu, J.,Jamali, H.,Ellman, J.A.,Lolis, E.,Anderson, K.S.,Bennett, A.M.; An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.; Sci.Signal., 13:-, 2020; PubMed: 32843541; DOI: 10.1126/scisignal.aba3043

Experimental method

X-RAY DIFFRACTION (2.7 Å)