6M2V

Crystal structure of UHRF1 SRA complexed with fully-mCHG DNA.

Summary for 6M2V

• Entry DOI: 10.2210/pdb6m2v/pdb
• Descriptor: DNA (5'-D(*TP*CP*AP*CP*GP*(5CM)P*TP*GP*CP*GP*TP*GP*A)-3'), E3 ubiquitin-protein ligase UHRF1 (3 entities in total)
• Functional Keywords: 5-methyl-cytosine, complex, epigenetics, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 4
• Total formula weight: 55680.54

Authors

Abhishek, S.,Nakarakanti, N.K.,Deeksha, W.,Rajakumara, E. (deposition date: 2020-03-01, release date: 2021-01-13, Last modification date: 2023-11-29)

• Primary citation: Abhishek, S.,Nakarakanti, N.K.,Deeksha, W.,Rajakumara, E.; Mechanistic insights into recognition of symmetric methylated cytosines in CpG and non-CpG DNA by UHRF1 SRA.; Int.J.Biol.Macromol., 170:514-522, 2021; PubMed: 33359809; DOI: 10.1016/j.ijbiomac.2020.12.149

Experimental method

X-RAY DIFFRACTION (3 Å)