6LYY

Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation.

Summary for 6LYY

• Entry DOI: 10.2210/pdb6lyy/pdb
• Related: 6LZ0 7CKO 7CKR 7DA5
• EMDB information: 30019 30020 30389 30391 30623
• Descriptor: Monocarboxylate transporter 1, Basigin, 3-methyl-5-[[(4~{R})-4-methyl-4-oxidanyl-1,2-oxazolidin-2-yl]carbonyl]-6-[[5-methyl-3-(trifluoromethyl)-1~{H}-pyrazol-4-yl]methyl]-1-propan-2-yl-thieno[2,3-d]pyrimidine-2,4-dione (3 entities in total)
• Functional Keywords: proton-coupled monocarboxylate transporter, mct1, basigin, anti-cancer, azd3965, bay-8002, 7acc2, single particle cryo-em, latate transporter, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 83763.30

Authors

Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Lei, J.,Yan, C. (deposition date: 2020-02-16, release date: 2020-12-23, Last modification date: 2024-03-27)

• Primary citation: Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Xu, H.,Lei, J.,Yan, C.; Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.; Cell, 184:370-, 2021; PubMed: 33333023; DOI: 10.1016/j.cell.2020.11.043

Experimental method

ELECTRON MICROSCOPY (3.2 Å)