6LU5

Crystal structure of BPTF-BRD with ligand DCBPin5 bound

Summary for 6LU5

• Entry DOI: 10.2210/pdb6lu5/pdb
• Descriptor: Nucleosome-remodeling factor subunit BPTF, 6-(1H-indol-5-yl)-N-methyl-2-methylsulfonyl-pyrimidin-4-amine (3 entities in total)
• Functional Keywords: bptf bromodomain, lysine acetylation, small-molecule inhibitor, high-throughput screening, biosynthetic protein, antitumor protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 13164.03

Authors

Lu, T.,Lu, H.B.,Wang, J.,Lin, H.,Lu, W.,Luo, C. (deposition date: 2020-01-25, release date: 2021-04-28, Last modification date: 2023-11-29)

• Primary citation: Lu, T.,Lu, H.B.,Wang, J.,Han, J.,Xiao, S.,Jiang, H.,Chen, Y.,Yang, F.,Li, Q.,Jiang, H.L.,Chen, K.X.,Lu, W.C.,Lin, H.,Luo, C.; Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.86527732574 Å)