6LT8

HSP90 in complex with KW-2478

Summary for 6LT8

Entry DOI	10.2210/pdb6lt8/pdb
Descriptor	Heat shock protein HSP 90-alpha, 2-[2-ethyl-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]carbonyl-3,5-bis(oxidanyl)phenyl]-~{N},~{N}-bis(2-methoxyethyl)ethanamide (3 entities in total)
Functional Keywords	hsp90, kw-2478, chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	28975.36
Authors	Cao, H.L. (deposition date: 2020-01-21, release date: 2021-01-27, Last modification date: 2023-11-29)
Primary citation	Li, H.J.,Wang, Q.S.,Han, W.,Zhou, H.,Li, P.,Zhou, F.,Qin, W.,Zhao, D.,Zhou, X.,He, C.X.,Xing, L.,Li, P.Q.,Jin, X.,Yu, F.,He, J.H.,Cao, H.L. Anti-NSCLC activity in vitro of Hsp90 N inhibitor KW-2478 and complex crystal structure determination of Hsp90 N -KW-2478. J.Struct.Biol., 213:107710-107710, 2021 Cited by PubMed: 33610655 DOI: 10.1016/j.jsb.2021.107710 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.593 Å)

Structure validation