6LS5
Structure of human liver FBPase complexed with covalent allosteric inhibitor
Summary for 6LS5
| Entry DOI | 10.2210/pdb6ls5/pdb |
| Descriptor | Fructose-1,6-bisphosphatase 1, 2-(ethyldisulfanyl)-1,3-benzothiazole, ADENOSINE MONOPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | fbpase, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 156819.51 |
| Authors | Yunyuan, H.,Rongrong, S.,Yixiang, X.,Shuaishuai, N.,Yanliang, R.,Jian, L.,Jian, W. (deposition date: 2020-01-17, release date: 2020-05-27, Last modification date: 2023-11-29) |
| Primary citation | Huang, Y.,Xu, Y.,Song, R.,Ni, S.,Liu, J.,Xu, Y.,Ren, Y.,Rao, L.,Wang, Y.,Wei, L.,Feng, L.,Su, C.,Peng, C.,Li, J.,Wan, J. Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction. J.Med.Chem., 63:6238-6247, 2020 Cited by PubMed: 32375478DOI: 10.1021/acs.jmedchem.0c00699 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.031 Å) |
Structure validation
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