6LN1

A natural inhibitor of DYRK1A for treatment of diabetes mellitus

Summary for 6LN1

Entry DOI	10.2210/pdb6ln1/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 1,3,5,8-tetrakis(oxidanyl)xanthen-9-one (3 entities in total)
Functional Keywords	anti-diabetic activity, desmethylbellidifolin, dyrk1a, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	81477.85
Authors	Li, H.,Chen, L.X.,Zheng, M.Z.,Zhang, Q.Z.,Zhang, C.L.,Wu, C.R.,Yang, K.Y.,Song, Z.R.,Wang, Q.Q.,Li, C.,Zhou, Y.R.,Chen, J.C. (deposition date: 2019-12-28, release date: 2021-10-06, Last modification date: 2023-11-22)
Primary citation	Zheng, M.,Zhang, Q.,Zhang, C.,Wu, C.,Yang, K.,Song, Z.,Wang, Q.,Li, C.,Zhou, Y.,Chen, J.,Li, H.,Chen, L. A natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes. Clin Transl Med, 11:e494-e494, 2021 Cited by PubMed: 34323401 DOI: 10.1002/ctm2.494 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.699 Å)

Structure validation