6LCY

Crystal structure of Synaptotagmin-7 C2B in complex with IP6

Summary for 6LCY

• Entry DOI: 10.2210/pdb6lcy/pdb
• Descriptor: Synaptotagmin-7, INOSITOL HEXAKISPHOSPHATE (3 entities in total)
• Functional Keywords: synaptotagmin-7, ip6, insulin secretion, exocytosis
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 17775.28

Authors

Zhang, Y.,Zhang, X.,Rao, F.,Wang, C. (deposition date: 2019-11-20, release date: 2021-03-03, Last modification date: 2023-11-22)

• Primary citation: Zhang, X.,Li, N.,Zhang, J.,Zhang, Y.,Yang, X.,Luo, Y.,Zhang, B.,Xu, Z.,Zhu, Z.,Yang, X.,Yan, Y.,Lin, B.,Wang, S.,Chen, D.,Ye, C.,Ding, Y.,Lou, M.,Wu, Q.,Hou, Z.,Zhang, K.,Liang, Z.,Wei, A.,Wang, B.,Wang, C.,Jiang, N.,Zhang, W.,Xiao, G.,Ma, C.,Ren, Y.,Qi, X.,Han, W.,Wang, C.,Rao, F.; 5-IP 7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis.; Nat Metab, 3:1400-1414, 2021; PubMed: 34663975; DOI: 10.1038/s42255-021-00468-7

Experimental method

X-RAY DIFFRACTION (2.301 Å)