6L59

Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT, Mg and ATP binding at allosteric site and Mg, ATP binding at active site.

Summary for 6L59

• Entry DOI: 10.2210/pdb6l59/pdb
• Descriptor: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: tca cycle, nad-isocitrate dehydrogenase, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 77355.44

Authors

Sun, P.,Ding, J. (deposition date: 2019-10-22, release date: 2020-04-29, Last modification date: 2023-11-22)

• Primary citation: Sun, P.,Bai, T.,Ma, T.,Ding, J.; Molecular mechanism of the dual regulatory roles of ATP on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.; Sci Rep, 10:6225-6225, 2020; PubMed: 32277159; DOI: 10.1038/s41598-020-63425-6

Experimental method

X-RAY DIFFRACTION (2.254 Å)