6KY6
Crystal structure of a thermostable aldo-keto reductase Tm1743 in complexs with inhibitor epalrestat in space group P3221cc
Summary for 6KY6
Entry DOI | 10.2210/pdb6ky6/pdb |
Related | 6KIK 6KIY |
Descriptor | 2,5-diketo-D-gluconic acid reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, ... (5 entities in total) |
Functional Keywords | aldo-ketone reductase, tolrestat, epalrestat, competitive inhibitor, oxidoreductase |
Biological source | Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) |
Total number of polymer chains | 2 |
Total formula weight | 65108.77 |
Authors | Zhang, C.Y.,Min, Z.Z.,Liu, X.M.,Wang, C.,Tang, W.R. (deposition date: 2019-09-16, release date: 2019-10-02, Last modification date: 2023-11-22) |
Primary citation | Zhang, C.,Min, Z.,Liu, X.,Wang, C.,Wang, Z.,Shen, J.,Tang, W.,Zhang, X.,Liu, D.,Xu, X. Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima. Febs Lett., 594:564-580, 2020 Cited by PubMed: 31573681DOI: 10.1002/1873-3468.13630 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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