6KBF

Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3

Summary for 6KBF

Entry DOI	10.2210/pdb6kbf/pdb
Descriptor	Lysine--tRNA ligase, LYSINE, (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydro-2~{H}-isoquinolin-1-one, ... (6 entities in total)
Functional Keywords	inhibitor, complex, ligase
Biological source	Plasmodium falciparum (isolate NF54)
Total number of polymer chains	2
Total formula weight	120974.00
Authors	Zhou, J.,Fang, P. (deposition date: 2019-06-24, release date: 2020-04-08, Last modification date: 2023-11-22)
Primary citation	Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P. Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15:1016-1025, 2020 Cited by PubMed: 32195573 DOI: 10.1021/acschembio.0c00032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation