6JW9

Crystal structure of E-64 inhibited falcipain 2 from Plasmodium falciparum, strain 3D7

Summary for 6JW9

Entry DOI	10.2210/pdb6jw9/pdb
Descriptor	Cysteine protease falcipain-2, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE (3 entities in total)
Functional Keywords	cysteine protease, haemoglobinase, drug-target, plasmodium falciparum, hydrolase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	2
Total formula weight	54771.77
Authors	Chakraborty, S.,Alam, B.,Biswas, S. (deposition date: 2019-04-18, release date: 2020-04-22, Last modification date: 2023-11-29)
Primary citation	Chakraborty, S.,Alam, B.,Biswas, S. New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain. Biochem.Biophys.Res.Commun., 590:145-151, 2022 Cited by PubMed: 34974303 DOI: 10.1016/j.bbrc.2021.12.080 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation