6J1Z

WWP2 semi-open conformation

Summary for 6J1Z

Entry DOI	10.2210/pdb6j1z/pdb
Descriptor	NEDD4-like E3 ubiquitin-protein ligase WWP2 (2 entities in total)
Functional Keywords	e3 ligase semi-open conformation, enzyme, auto-inhibition., ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	57131.45
Authors	Liu, Z.H. (deposition date: 2018-12-30, release date: 2019-07-24, Last modification date: 2023-11-22)
Primary citation	Wang, Z.,Liu, Z.,Chen, X.,Li, J.,Yao, W.,Huang, S.,Gu, A.,Lei, Q.Y.,Mao, Y.,Wen, W. A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun, 10:3162-3162, 2019 Cited by PubMed: 31320636 DOI: 10.1038/s41467-019-11224-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation