6HKB
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 3
Summary for 6HKB
Entry DOI | 10.2210/pdb6hkb/pdb |
Descriptor | 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | protein-protein interaction, fragment, tethering, stabilizer, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 27815.14 |
Authors | Sijbesma, E.,Hallenbeck, K.K.,Leysen, S.,Arkin, M.R.,Ottmann, C. (deposition date: 2018-09-06, release date: 2019-02-27, Last modification date: 2024-01-17) |
Primary citation | Sijbesma, E.,Hallenbeck, K.K.,Leysen, S.,de Vink, P.J.,Skora, L.,Jahnke, W.,Brunsveld, L.,Arkin, M.R.,Ottmann, C. Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141:3524-3531, 2019 Cited by PubMed: 30707565DOI: 10.1021/jacs.8b11658 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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