6HEP

Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768

Summary for 6HEP

Entry DOI	10.2210/pdb6hep/pdb
Descriptor	14-3-3 protein beta/alpha, Cystic fibrosis transmembrane conductance regulator, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (4 entities in total)
Functional Keywords	14-3-3, cftr, multivalency, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	114879.61
Authors	Stevers, L.M.,Ottmann, C.,Brunsveld, L. (deposition date: 2018-08-20, release date: 2018-10-24, Last modification date: 2018-11-07)
Primary citation	Stevers, L.M.,de Vink, P.J.,Ottmann, C.,Huskens, J.,Brunsveld, L. A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions. J. Am. Chem. Soc., 140:14498-14510, 2018 Cited by PubMed: 30296824 DOI: 10.1021/jacs.8b09618 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation