6HCA

STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION

Summary for 6HCA

Entry DOI	10.2210/pdb6hca/pdb
Descriptor	Glutamate receptor 2,Glutamate receptor 2, SULFATE ION, GLYCEROL, ... (7 entities in total)
Functional Keywords	glua2-s1s2j, ampa receptor, ligand-binding domain, positive allosteric modulator, membrane protein, signaling protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	60956.19
Authors	Laulumaa, S.,Hansen, K.V.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2018-08-14, release date: 2019-04-03, Last modification date: 2024-01-17)
Primary citation	Laulumaa, S.,Hansen, K.V.,Masternak, M.,Drapier, T.,Francotte, P.,Pirotte, B.,Frydenvang, K.,Kastrup, J.S. Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. Acs Med.Chem.Lett., 10:243-247, 2019 Cited by PubMed: 30891120 DOI: 10.1021/acsmedchemlett.8b00369 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.882 Å)

Structure validation