6H3E

Receptor-bound Ghrelin conformation

Summary for 6H3E

• Entry DOI: 10.2210/pdb6h3e/pdb
• NMR Information: BMRB: 34303
• Descriptor: Appetite-regulating hormone, octan-1-amine (2 entities in total)
• Functional Keywords: neuropeptide, acyl chain, growth hormone secretagogue receptor, gpcr, lipopeptide hormone, obesity, diabetes, addiction., hormone
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 2259.54

Authors

Ferre, G.,Damian, M.,M'Kadmi, C.,Saurel, O.,Czaplicki, G.,Demange, P.,Marie, J.,Fehrentz, J.A.,Baneres, J.L.,Milon, A. (deposition date: 2018-07-18, release date: 2019-07-24, Last modification date: 2023-06-14)

• Primary citation: Ferre, G.,Louet, M.,Saurel, O.,Delort, B.,Czaplicki, G.,M'Kadmi, C.,Damian, M.,Renault, P.,Cantel, S.,Gavara, L.,Demange, P.,Marie, J.,Fehrentz, J.A.,Floquet, N.,Milon, A.,Baneres, J.L.; Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain.; Proc.Natl.Acad.Sci.USA, 116:17525-17530, 2019; PubMed: 31416915; DOI: 10.1073/pnas.1905105116

Experimental method

SOLUTION NMR