6H0B

Crystal structure of the human GalNAc-T4 in complex with UDP, manganese and the diglycopeptide 6.

Summary for 6H0B

• Entry DOI: 10.2210/pdb6h0b/pdb
• Descriptor: Polypeptide N-acetylgalactosaminyltransferase 4, ALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO-GLY, 1,2-ETHANEDIOL, ... (8 entities in total)
• Functional Keywords: galnac-ts, galnac-t4, short-range glycosylation preference, long-range glycosylation preference, (glyco)peptides, std-nmr, molecular dynamics, enzyme kinetics, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 137938.85

Authors

de las Rivas, M.,Daniel, E.J.P.,Coelho, H.,Lira-Navarrete, E.,Raich, L.,Companon, I.,Diniz, A.,Lagartera, L.,Jimenez-Barbero, J.,Clausen, H.,Rovira, C.,Marcelo, F.,Corzana, F.,Gerken, T.A.,Hurtado-Guerrero, R. (deposition date: 2018-07-08, release date: 2018-10-10, Last modification date: 2024-01-17)

• Primary citation: de Las Rivas, M.,Paul Daniel, E.J.,Coelho, H.,Lira-Navarrete, E.,Raich, L.,Companon, I.,Diniz, A.,Lagartera, L.,Jimenez-Barbero, J.,Clausen, H.,Rovira, C.,Marcelo, F.,Corzana, F.,Gerken, T.A.,Hurtado-Guerrero, R.; Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.; ACS Cent Sci, 4:1274-1290, 2018; PubMed: 30276263; DOI: 10.1021/acscentsci.8b00488

Experimental method

X-RAY DIFFRACTION (1.8 Å)