6GPL

Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4k6d-Man

Summary for 6GPL

Entry DOI	10.2210/pdb6gpl/pdb
Descriptor	GDP-mannose 4,6 dehydratase, BICINE, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},6~{R})-6-methyl-3,4-bis(oxidanyl)-5-oxidanylidene-oxan-2-yl] hydrogen phosphate, ... (6 entities in total)
Functional Keywords	structural genomics, structural genomics consortium, sgc, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	166270.57
Authors	Pfeiffer, M.,Krojer, T.,Johansson, C.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Nidetzky, B.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2018-06-06, release date: 2018-07-18, Last modification date: 2024-05-15)
Primary citation	Pfeiffer, M.,Johansson, C.,Krojer, T.,Kavanagh, K.L.,Oppermann, U.,Nidetzky, B. A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase. Acs Catalysis, 9:2962-2968, 2019 Cited by PubMed: 30984471 DOI: 10.1021/acscatal.9b00064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation