6GJG

Plasmodium falciparum dihydroorotate dehydrogenase DHODH in complex with 3,6-dimethyl-N-(4-(trifluoromethyl)phenyl)-(1,2)oxazolo(5,4-d)pyrimidin-4-amine

Summary for 6GJG

• Entry DOI: 10.2210/pdb6gjg/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total)
• Functional Keywords: enzyme, dhodh, flavoprotein
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 2
• Total formula weight: 92613.23

Authors

Rowland, P. (deposition date: 2018-05-16, release date: 2018-09-19)

• Primary citation: Kokkonda, S.,El Mazouni, F.,White, K.L.,White, J.,Shackleford, D.M.,Lafuente-Monasterio, M.J.,Rowland, P.,Manjalanagara, K.,Joseph, J.T.,Garcia-Perez, A.,Fernandez, J.,Gamo, F.J.,Waterson, D.,Burrows, J.N.,Palmer, M.J.,Charman, S.A.,Rathod, P.K.,Phillips, M.A.; Isoxazolopyrimidine-Based Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity.; ACS Omega, 3:9227-9240, 2018; PubMed: 30197997; DOI: 10.1021/acsomega.8b01573

Experimental method

X-RAY DIFFRACTION (1.99 Å)