6GJB

Erk2 signalling protein

Summary for 6GJB

Entry DOI	10.2210/pdb6gjb/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[4-[1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-2-oxidanylidene-pyridin-4-yl]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate, ... (4 entities in total)
Functional Keywords	erk2, inhibitor, reversible probe, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43689.37
Authors	O'Reilly, M. (deposition date: 2018-05-16, release date: 2019-01-02)
Primary citation	Lebraud, H.,Surova, O.,Courtin, A.,O'Reilly, M.,Valenzano, C.R.,Nordlund, P.,Heightman, T.D. Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe. Chem Sci, 9:8608-8618, 2018 Cited by PubMed: 30568786 DOI: 10.1039/c8sc02754d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation