6GHP

14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc

Summary for 6GHP

• Entry DOI: 10.2210/pdb6ghp/pdb
• Descriptor: 14-3-3 protein sigma, Potassium channel subfamily K member 9, ~{N}-[(2~{S})-2-[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-8-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(2-methylbut-3-en-2-yloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,9-bis(oxidanyl)-6-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]propyl]ethanamide, ... (6 entities in total)
• Functional Keywords: potassium channel, natural product, ppi, stabilizer, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28123.85

Authors

Andrei, S.A.,de Vink, P.J.,Brunsveld, L.,Ottmann, C.,Higuchi, Y. (deposition date: 2018-05-08, release date: 2018-08-01, Last modification date: 2018-10-17)

• Primary citation: Andrei, S.A.,de Vink, P.,Sijbesma, E.,Han, L.,Brunsveld, L.,Kato, N.,Ottmann, C.,Higuchi, Y.; Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions.; Angew. Chem. Int. Ed. Engl., 57:13470-13474, 2018; PubMed: 30025189; DOI: 10.1002/anie.201806584

Experimental method

X-RAY DIFFRACTION (1.95 Å)