6GDP

Trypanosoma brucei PTR1 in complex with inhibitor 4l (F162)

Summary for 6GDP

Entry DOI	10.2210/pdb6gdp/pdb
Related	6GCK 6GCL 6GCP 6GCQ 6GD0 6GD4 6GDO
Descriptor	Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-azanyl-~{N}-(diphenylmethyl)-1,3-benzothiazole-6-carboxamide, ... (6 entities in total)
Functional Keywords	trypanosoma brucei, pteridine reductase, ptr1, tbptr1, benzothiazole, oxidoreductase
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	4
Total formula weight	127309.67
Authors	Pozzi, C.,Landi, G.,Mangani, S. (deposition date: 2018-04-24, release date: 2019-04-03, Last modification date: 2024-01-17)
Primary citation	Linciano, P.,Pozzi, C.,Iacono, L.D.,di Pisa, F.,Landi, G.,Bonucci, A.,Gul, S.,Kuzikov, M.,Ellinger, B.,Witt, G.,Santarem, N.,Baptista, C.,Franco, C.,Moraes, C.B.,Muller, W.,Wittig, U.,Luciani, R.,Sesenna, A.,Quotadamo, A.,Ferrari, S.,Pohner, I.,Cordeiro-da-Silva, A.,Mangani, S.,Costantino, L.,Costi, M.P. Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. J.Med.Chem., 62:3989-4012, 2019 Cited by PubMed: 30908048 DOI: 10.1021/acs.jmedchem.8b02021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation