6G3C
Crystal Structure of JAK2-V617F pseudokinase domain in complex with Compound 2
Summary for 6G3C
Entry DOI | 10.2210/pdb6g3c/pdb |
Descriptor | Tyrosine-protein kinase, 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | janus protein kinase, pseudokinase, phosphotransferase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 63895.31 |
Authors | Dekker, C.,Hinniger, A. (deposition date: 2018-03-24, release date: 2019-03-27, Last modification date: 2024-01-17) |
Primary citation | McNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J. Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain. Acs Chem.Biol., 14:587-593, 2019 Cited by PubMed: 30763067DOI: 10.1021/acschembio.8b00722 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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