6FUJ
Complement factor D in complex with the inhibitor N-(3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)-3-methylbutanamide
Summary for 6FUJ
Entry DOI | 10.2210/pdb6fuj/pdb |
Descriptor | Complement factor D, ~{N}-[3-[3-(aminomethyl)phenyl]phenyl]-3-methyl-butanamide (3 entities in total) |
Functional Keywords | serine protease, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 149281.87 |
Authors | Mac Sweeney, A.,Ostermann, N.,Vulpetti, A.,Maibaum, J.,Erbel, P.,Lorthiois, E.,Yoon, T.,Randl, S.,Ruedisser, S. (deposition date: 2018-02-27, release date: 2018-06-06) |
Primary citation | Vulpetti, A.,Ostermann, N.,Randl, S.,Yoon, T.,Mac Sweeney, A.,Cumin, F.,Lorthiois, E.,Rudisser, S.,Erbel, P.,Maibaum, J. Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett, 9:490-495, 2018 Cited by PubMed: 29795765DOI: 10.1021/acsmedchemlett.8b00104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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