6FQQ

Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA

Summary for 6FQQ

• Entry DOI: 10.2210/pdb6fqq/pdb
• Related: 6FQP
• Descriptor: Homeobox protein TGIF1, DNA (5'-D(P*AP*TP*TP*GP*AP*CP*AP*GP*CP*TP*GP*TP*CP*AP*AP*T)-3'), CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: homeobox, three-amino acid loop extension, tgf-beta pathway, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 52910.36

Authors

Guca, E.,Macias, M.J. (deposition date: 2018-02-14, release date: 2018-07-25, Last modification date: 2024-01-17)

• Primary citation: Guca, E.,Sunol, D.,Ruiz, L.,Konkol, A.,Cordero, J.,Torner, C.,Aragon, E.,Martin-Malpartida, P.,Riera, A.,Macias, M.J.; TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-beta signaling.; Nucleic Acids Res., 46:9220-9235, 2018; PubMed: 30060237; DOI: 10.1093/nar/gky680

Experimental method

X-RAY DIFFRACTION (3.25000253887 Å)