6FJ1

Structure of the Ldtfm-avibactam carbamoyl enzyme

Summary for 6FJ1

Entry DOI	10.2210/pdb6fj1/pdb
Descriptor	L,D-TRANSPEPTIDASE, 3,6,9,12,15-PENTAOXAHEPTADECANE, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, ... (6 entities in total)
Functional Keywords	l, d-transpeptidation, peptidoglycan, antibiotic resistance, avibactam, nxl104, antibiotic, hydrolase
Biological source	Enterococcus faecium (Streptococcus faecium)
Total number of polymer chains	3
Total formula weight	88754.71
Authors	Li de la Sierra Gallay, I.,Iannazzo, L.,Compain, F.,Fonvielle, M.,van Tilbeurgh, H.,Edoo, Z.,Arthur, M.,Etheve-Quelquejeu, M.,Hugonnet, J. (deposition date: 2018-01-19, release date: 2019-01-30, Last modification date: 2024-02-07)
Primary citation	Edoo, Z.,Iannazzo, L.,Compain, F.,Li de la Sierra Gallay, I.,van Tilbeurgh, H.,Fonvielle, M.,Bouchet, F.,Le Run, E.,Mainardi, J.L.,Arthur, M.,Etheve-Quelquejeu, M.,Hugonnet, J.E. Synthesis of Avibactam Derivatives and Activity on beta-Lactamases and Peptidoglycan Biosynthesis Enzymes of Mycobacteria. Chemistry, 24:8081-8086, 2018 Cited by PubMed: 29601108 DOI: 10.1002/chem.201800923 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.69 Å)

Structure validation